The John Rinn lab (Harvard, Cambridge, US) utilizes the CRISPR system to bridge RNA cargos onto specific genomic loci enabling the targeting of different RNAs or ribonucleoprotein particles to DNA. The spectacular technology is based on using the dead (inactive) Cas9 /gRNA linked to an RNA of choice (either covalently or by hybridization). Interestingly various RNA cargo could be linked, including natural long-non coding RNAs, aptamers or pools of RNA sequences. This technology has diverse applications, i.e. analysis of lncRNA function, screening for RNA based drugs influencing specific genomic loci, imaging, modular transcriptional regulation.
If you work with lncRNA or RNPs you should check it out!
http://www.nature.com/nmeth/journal/vaop/ncurrent/full/nmeth.3433.html
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