Friday, March 6, 2015

Speeding up human evolution via genome editing?

I came across this scary article recently. By reading the article you can get a sense how astonishingly close we are to create genetically modified human embryos. Fact is, the first gene modified monkeys were born in China last year, and rumors suggest the first modified human embryos are already created somewhere in China too. Implanting these embryos would give rise to the first human beings, whose code of life has been directly manipulated. And there is no doubt that using CRISPR technology this seems simple. I think - being a researcher - I could learn it in a few months or so. It's pretty much straightforward. But the question remains, why would anyone on earth do this?

 It is important to emphasize that medical reasons to gene edit embryos are practically non-existing. This must be done on in vitro fertilized embryos, which could be screened for genetic diseases anyway (this is a already a 'treatment option' for those couples who have certain mutant genes). In this case, only the normal gene carrying embryos would be implanted into the mother, avoiding the need for genome editing.  

So gene editing would only help those couples who altogether carry at least 3 gene defects on the same gene! (except for the very unlikely case of carrying 2 dominantly inherited alleles in the same parent). This is a very rare case, so companies try to raise money for another potential application - to boost up intelligence or strength. In a recent survey, 15% of Americans would agree to carry out gene modifications on embryos in order to make the baby more intelligent. I'm not expecting that such a treatment option would be available in the near future, given the complexity of intelligence development. But in the distant future, targeted gene modifications will be feasible in favor of accelerated human evolution.

Check out the article here.

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